Full Professor, Head of the Laboratory of Medical Immunology

Supervisor ESR15.

“Continuous monitoring of inflammatory biomarkers at nanomolar to picomolar concentrations will have a significant impact on the diagnosis and treatment of severely ill patients, including patients with sepsis and inflammatory diseases. Our main goal in this project is to test the engineered biosensors in in vitro cell systems.”

De Jonge is a passionate scientist with more than 20 years of experience in academic as well as in industrial R&D. Marien de Jonge’s main research interest is focused on understanding host-pathogen interactions and mucosal immune responses to improve prevention, diagnosis and treatment of viral and bacterial respiratory tract infections. His group explores novel intranasal and intradermal vaccination strategies and works on the identification of the immune correlates of protection. In addition, his group aims to develop innovative methods to diagnose and monitor immune-related diseases.

De Jonge has a background in molecular microbiology, immunology and infectious diseases. He obtained a M.Sc. degree at the science faculty of the Vrije Universiteit in Amsterdam and a PhD degree at the medical faculty of the University of Amsterdam. He was post-doctoral fellow for 2,5 years at Institut Pasteur in Paris and worked as projectleader within the Vaccine R&D of Merck Sharpe and Dohme for 4,5 years, after which he became senior scientist and 1,5 years later head of the Laboratory of Pediatric Infectious Diseases at the Radboud University Medical Center (RUMC) in Nijmegen, the Netherlands. He is chair of the Royal Dutch Society for Microbiology and since 2021 he is the head of the Laboratory of Medical Immunology at the RUMC. In 2023 he was appointed professor of ‘Infection and Immunity’ at the Medical Faculty of the Radboud University in Nijmegen.

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study. Jackson HR, Zandstra J, Menikou S, Hamilton MS, McArdle AJ, Fischer R, Thorne AM, Huang H, Tanck MW, Jansen MH, De T, Agyeman PKA, Von Both U, Carrol ED, Emonts M, Eleftheriou I, Van der Flier M, Fink C, Gloerich J, De Groot R, Moll HA, Pokorn M, Pollard AJ, Schlapbach LJ, Tsolia MN, Usuf E, Wright VJ, Yeung S, Zavadska D, Zenz W, Coin LJM, Casals-Pascual C, Cunnington AJ, Martinon-Torres F, Herberg JA, de Jonge MI*, Levin M*, Kuijpers TW*, Kaforou M*; PERFORM consortium.
Lancet Digit Health. 2023 Nov;5(11):e774-e785. doi: 10.1016/S2589-7500(23)00149-8. (* contributed equally to this work)

Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens. Willems E, Gloerich J, Suppers A, van der Flier M, van den Heuvel LP, van de Kar N, Philipsen RHLA, van Dael M, Kaforou M, Wright VJ, Herberg JA, Torres FM, Levin M, de Groot R, van Gool AJ, Lefeber DJ, Wessels HJCT*, de Jonge MI*; PERFORM consortium.
iScience. 2023 Jul 4;26(8):107257. doi: 10.1016/j.isci.2023.107257. (* contributed equally to this work)

Quantitative multiplex profiling of the complement system to diagnose complement-mediated diseases. Willems E, Lorés-Motta L, Zanichelli A, Suffritti C, van der Flier M, van der Molen RG, Langereis JD, van Drongelen J, van den Heuvel LP, Volokhina E, van de Kar NC, Keizer-Garritsen J, Levin M, Herberg JA, Martinon-Torres F, Wessels HJ, de Breuk A, Fauser S, Hoyng CB, den Hollander AI, de Groot R, van Gool AJ, Gloerich J, de Jonge MI.
Clin Transl Immunology. 2020 Dec 9;9(12):e1225. doi: 10.1002/cti2.1225.

Viral-bacterial (co-)occurrence in the upper airways and the risk of childhood pneumonia in resource-limited settings. Ngocho JS, Minja L, van der Gaast-de Jongh CE, Rahamat-Langendoen JC, Langereis JD, Mmbaga BT, de Jonge MI.
J Infect. 2020 Aug;81(2):213-220. doi: 10.1016/j.jinf.2020.06.013.

Biosynthetic homeostasis and resilience of the complement system in health and infectious disease. Willems E, Alkema W, Keizer-Garritsen J, Suppers A, van der Flier M, Philipsen RHLA, van den Heuvel LP, Volokhina E, van der Molen RG, Herberg JA, Levin M, Wright VJ, Ahout IML, Ferwerda G, Emonts M, Boeddha NP, Rivero-Calle I, Torres FM, Wessels HJCT, de Groot R, van Gool AJ, Gloerich J, de Jonge MI.
EBioMedicine. 2019 Jul;45:303-313. doi: 10.1016/j.ebiom.2019.06.008. 

The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease. Cremers AJH, Mobegi FM, van der Gaast-de Jongh C, van Weert M, van Opzeeland FJ, Vehkala M, Knol MJ, Bootsma HJ, Välimäki N, Croucher NJ, Meis JF, Bentley S, van Hijum SAFT, Corander J, Zomer AL, Ferwerda G, de Jonge MI.
Clin Infect Dis. 2019 Jan 1;68(1):61-69. doi: 10.1093/cid/ciy417.

Selective counting and sizing of single virus particles using fluorescent aptamer-based nanoparticle tracking analysis. Szakács Z, Mészáros T, de Jonge MI, Gyurcsányi RE.
Nanoscale. 2018 Aug 7;10(29):13942-13948. doi: 10.1039/c8nr01310a.