Dr. Marien de Jonge

Associate Professor, Head of the Laboratory of Medical Immunology

Supervisor ESR15.

“Continuous monitoring of inflammatory biomarkers at nanomolar to picomolar concentrations will have a significant impact on the diagnosis and treatment of severely ill patients, including patients with sepsis and inflammatory diseases. Our main goal in this project is to test the engineered biosensors in in vitro cell systems.”

De Jonge is a passionate scientist with more than 15 years of experience in academic as well as in industrial R&D. Marien de Jonge’s main research interest is focused on understanding host-pathogen interactions and mucosal immune responses to improve prevention, diagnosis and treatment of viral and bacterial respiratory tract infections in children. He has extensive experience in the field of vaccine research and the development of diagnostics. He has been Head of the Laboratory of Pediatric Infectious Diseases at Radboud University Medical Center for more than 5 years and recently became the head of the Laboratory of Medical Immunology. He is chair of the Royal Dutch Society for Microbiology since 2017.

De Jonge has a background in molecular microbiology, immunology and infectious diseases. He obtained a M.Sc. degree at the science faculty of the Vrije Universiteit in Amsterdam and a PhD degree at the medical faculty of the University of Amsterdam. He was post-doctoral fellow for 2,5 years at Institut Pasteur in Paris in the group of Prof. Stewart Cole and worked as projectleader within the Vaccine R&D of Merck Sharpe and Dohme for 4,5 years, after which he became senior scientist and 1,5 years later head of the Laboratory of Pediatric Infectious Diseases. Since 1st March 2021 he became the head of the Laboratory of Medical Immunology.

Willems E, Lorés-Motta L, Zanichelli A, Suffritti C, van der Flier M, van der Molen RG, Langereis JD, van Drongelen J, van den Heuvel LP, Volokhina E, van de Kar NC, Keizer-Garritsen J, Levin M, Herberg JA, Martinon-Torres F, Wessels HJ, de Breuk A, Fauser S, Hoyng CB, den Hollander AI, de Groot R, van Gool AJ, Gloerich J, de Jonge MI. Quantitative multiplex profiling of the complement system to diagnose complement-mediated diseases. Clin Transl Immunology. 2020 Dec 9;9(12):e1225. doi: 10.1002/cti2.1225.

Ngocho JS, Minja L, van der Gaast-de Jongh CE, Rahamat-Langendoen JC, Langereis JD, Mmbaga BT, de Jonge MI. Viral-bacterial (co-)occurrence in the upper airways and the risk of childhood pneumonia in resource-limited settings. J Infect. 2020 Aug;81(2):213-220. doi: 10.1016/j.jinf.2020.06.013.

Willems E, Alkema W, Keizer-Garritsen J, Suppers A, van der Flier M, Philipsen RHLA, van den Heuvel LP, Volokhina E, van der Molen RG, Herberg JA, Levin M, Wright VJ, Ahout IML, Ferwerda G, Emonts M, Boeddha NP, Rivero-Calle I, Torres FM, Wessels HJCT, de Groot R, van Gool AJ, Gloerich J, de Jonge MI. Biosynthetic homeostasis and resilience of the complement system in health and infectious disease. EBioMedicine. 2019 Jul;45:303-313. doi: 10.1016/j.ebiom.2019.06.008. 

Cremers AJH, Mobegi FM, van der Gaast-de Jongh C, van Weert M, van Opzeeland FJ, Vehkala M, Knol MJ, Bootsma HJ, Välimäki N, Croucher NJ, Meis JF, Bentley S, van Hijum SAFT, Corander J, Zomer AL, Ferwerda G, de Jonge MI. The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease. Clin Infect Dis. 2019 Jan 1;68(1):61-69. doi: 10.1093/cid/ciy417.

Szakács Z, Mészáros T, de Jonge MI, Gyurcsányi RE. Selective counting and sizing of single virus particles using fluorescent aptamer-based nanoparticle tracking analysis. Nanoscale. 2018 Aug 7;10(29):13942-13948. doi: 10.1039/c8nr01310a.

Ederveen THA, Ferwerda G, Ahout IM, Vissers M, de Groot R, Boekhorst J, Timmerman HM, Huynen MA, van Hijum SAFT, de Jonge MI. Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses. Microbiome. 2018 Jan 11;6(1):10. doi: 10.1186/s40168-017-0395-y.

van den Kieboom CH, van der Beek SL, Mészáros T, Gyurcsányi RE, Ferwerda G, de Jonge MI. Aptasensors for viral diagnostics. Trends Analyt Chem. 2015 Dec;74:58-67. doi: 10.1016/j.trac.2015.05.012.