Open Positions

CONSENSE will provide exceptional training to 15 ESRs, allowing them to develop professionally and perform world-class research that will fundamentally advance the field of continuous biomolecular monitoring for healthcare.

The training program educates ESRs with unique training topics from complementary research in science, technology, and industry, fosters important transferable skills, and provides unique insight into a network of large medical tech companies, clinical experts and leading pioneers in biomolecular switch engineering.

Browse the available ESR jobs below:

Host Institution: FOx Biosystems NV

Supervisor: Dr. Filip Delport

Project Description:

FOx Biosystems develops and sells instruments to quantify and characterize biomolecular interactions, using Fiber optic surface plasmon resonance (FO-SPR), for applications in biological research and healthcare. The technology is used both label free, e.g for kinetic binding characterization, and labelled with gold nanoparticles, for fast and sensitive quantification.

The goal of this project is to proof feasibility of CONSENSE technology towards continuous bioprocess monitoring and taking the next step by providing a proof-of-concept demonstrator at system level. Within the project a cell-based model system will be accessible with a dynamic behaviour. Realtime biological assays will be used to generate information on the biology of response dynamics.

In the project the ESR at FOx Biosystems will study the potential of a DNA nanoswitch concept (see e.g. ESR 12) on the FO-SPR platform for continuous protein monitoring. The ESR will:

1) Test an internal reference on the optical fiber to compensate for internal (e.g. light source fluctuations) and external perturbations (e.g. temperature fluctuations).

2) Build a demonstrator to integrate the sensor probe into the cell-based bioreactor product flow both for sample and optical interaction.

3) Modify a nanoswitch concept for detecting proteins in a relevant model case.

4) Generate the feasibility dataset on the entire biosensor system solution for its performance characteristics (stability, sensitivity, specificity, etc.) in a cell culture bioreactor production flow toward an ELISA benchmark.

Expected Results:

1) An improved FO-SPR biosensor with a self-referencing system validated in lab conditions.

2) Feasibility of optical + continuous sensing with an FO-SPR bio-assay for protein monitoring in buffer.

3) Conceptual designs and feasibility of demonstrator systems integrated in the bioprocess flow.

4) A proven self-referencing FO-SPR biosensor for continuous monitoring of proteins in a cell culture with a dose-response data of a model assay.

5) a PhD thesis supported by KU Leuven.

Planned Secondments:

1) TU/e, Merkx, M16, 4 months: Feasibility study of DNA based biosensing concept for antibody based bioassays. 2) Philips, Lieshout, M24, 2 months: Technology assessment for medical applications.

Essential Background: Candidates need to have a scientific background in e.g. chemistry, physics, biomedical engineering, bionanotechnology, or related disciplines.

Desirable Background: Candidates with optical and instrument experience is a plus. Furthermore a strong analytical and structured mindset with a can-do attitude are appreciated.

Learn more about the job and the application process